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Anti Cdc42 Mouse Monoclonal Antibody

Cdc42 [26008]
[100 µL]
$199.00

Catalog Number:  26008
Gene Symbol:  Cdc42
Description:   Anti-Cdc42 Mouse Monoclonal Antibody
Background:   Small GTPases are a super-family of cellular signaling regulators. Cdc42 belongs to the Rho sub-family of GTPases that regulate cell motility, cell division, and gene transcription. GTP binding increases the activity of Cdc42, and the hydrolysis of GTP to GDP renders it inactive. GTP hydrolysis is aided by GTPase activating proteins (GAPs), while exchange of GDP for GTP is facilitated by guanine nucleotide exchange factors (GEFs).
Immunogen:   Recombinant full length protein of Cdc42
Applications:   ELISA, WB, IHC
Recommended Dilutions:   ELISA 1:100-1:5000, WB 1:100-1:2000
Concentration:   1 mg/ml
Host:   Mouse
Format:   Liquid
Clonality:   Monoclonal
Isotype:   IgG
Purity:   Purified from ascites
Storage buffer:
Preservative:  no
Constituents:  PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Species Reactivity:  Cdc42 antibody recognizes Cdc42 from vertebrates.
Storage Conditions:  Store at -20°C. Avoid freeze / thaw cycles
Download Datasheet:  
Western blot:  
Western blot analysis of Cdc42 proteins. MEF whole-cell lysate was used for western blot with the monoclonal anti-Cdc42 antibody (cat # 26008).

Publications:
1.  Vibrio parahaemolyticus Effector Proteins Suppress Inflammasome Activation by Interfering with Host Autophagy Signaling
    PLoS Pathog. 2013 Jan;9(1):e1003142
2.  Interferon gamma induces actin polymerization, Rac1 activation and down regulates phagocytosis in human monocytic cells
    Cytokine. 2012 Jan;57(1):158-68
3.  Invadopodia and rolling-type motility are specific features of highly invasive p190bcr-abl leukemic cells
    European Journal of Cell Biology Volume 91, Issues 11–12, November–December 2012, Pages 978–987
4.  Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex
    J Cell Biol. 2012 Aug 20;198(4):677-93
5.  Polarized migration of lymphatic endothelial cells is critically dependent on podoplanin regulation of Cdc42
    Am J Physiol Lung Cell Mol Physiol. 2011 Jan;300(1):L32-42
6.  The Aarskog-Scott Syndrome Protein Fgd1 Regulates Podosome Formation and Extracellular Matrix Remodeling in Transforming Growth Factor beta-Stimulated Aortic Endothelial Cells
    Mol Cell Biol. 2011 Nov;31(22):4430-41
7.  MMP-9 and CXCL8/IL-8 Are Potential Therapeutic Targets in Epidermolysis Bullosa Simplex
    PLoS One. 2013 Jul 19;8(7):e70123
8.  p21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils
    PLoS One. 2013 Sep 3;8(9):e73063
9.  The Cdc42 Guanine Nucleotide Exchange Factor FGD6 Coordinates Cell Polarity and Endosomal Membrane Recycling in Osteoclasts
    J Biol Chem. 2014 Jun 27;289(26):18347-59
10.  Cdc42 Inhibitor and Uses Thereof
    United States Patent Application 20140194451
11.  The α4 Nicotinic Receptor Promotes CD4+ T-Cell Proliferation and a Helper T-Cell Immune Response
    Molecular Pharmacology January 2014 vol. 85 no. 1 50-61





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